Congenital CMV (cCMV) Resources for Professionals

As Minnesota is the first state in the country to include universal newborn screening for congenital cytomegalovirus (cCMV), health care professionals statewide will be handling newborn screening results and management/care issues not faced by anyone else before. These resources are provided to make those first steps better informed and to help health care staff and administration feel confident in their care.

As every new disorder is added to population-based screening, we learn more about the disorder and often find increased numbers of mildly affected infants who were not previously recognized. The MDH Public Health Laboratory has made a strong commitment to sharing data about infants identified with cCMV in order to allow clinicians to offer the best care possible.

CMV resources to share with families

• Family Fact Sheet: Cytomegalovirus Detected (PDF)
• Babies Born with Congenital Cytomegalovirus (cCMV) | CDC
• Improving the Identification and Management of Congenital CMV Infection (video) │ Colorado Associate of the Deaf
• National CMV Foundation – Cytomegalovirus (CMV) | National CMV Foundation
• Minnesota Deaf or Hard of Hearing Support & Information | Resources for Families of Children who are Deaf or Hard of Hearing | Minnesota Hands & Voices
• Cytomegalovirus (CMV) and Congenital CMV (cCMV)

Resources for health care providers

International consensus recommendations for prevention, diagnosis, and therapy

• 2017 Consensus Statement │ The Lancet

Overviews

• Cytomegalovirus Infection | Red Book: 2021–2024 Report of the Committee on Infectious Diseases | Red Book Online | American Academy of Pediatrics
• Congenital cytomegalovirus infection: Management and outcome - UpToDate
• Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management | NeoReviews | American Academy of Pediatrics
• Congenital cytomegalovirus: Impact on child health - PMC
• Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention - PMC
• Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening - PMC
• Emerging Concepts in Congenital Cytomegalovirus | Pediatrics | American Academy of Pediatrics

Newborn screening

• Ontario Congenital Cytomegalovirus | CHEO NSO
• Sensitivity of Dried Blood Spot Testing for Detection of Congenital Cytomegalovirus Infection - PMC
• Analysis of archived newborn dried blood spots (DBS) identifies congenital cytomegalovirus as a major cause of unexplained pediatric sensorineural hearing loss - ScienceDirect
• Assessment of Congenital Cytomegalovirus Prevalence Among Newborns in Minnesota During the COVID-19 Pandemic - PMC
• Public health and laboratory considerations regarding newborn screening for congenital cytomegalovirus - Dollard - 2010 - Journal of Inherited Metabolic Disease - Wiley Online Library

Hearing loss

• Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection - PMC
• Hearing outcome in congenitally CMV infected children in Finland – Results from follow-up after three years age | PubMed
• A High Risk of Missing Congenital Cytomegalovirus-Associated Hearing Loss through Newborn Hearing Screening in Japan - PMC

Anti-viral therapy

• Antiviral Therapy and Its Long-Term Impact on Hearing Loss Caused by Congenital Cytomegalovirus: Much Remains to Be Learned! | Journal of the Pediatric Infectious Diseases Society | Oxford Academic
• Changes in valganciclovir use among infants with congenital CMV diagnosis in the United States, 2009-2015 and 2016-2019 - ScienceDirect
• Progressive, Long-Term Hearing Loss in Congenital CMV Disease After Ganciclovir Therapy | Journal of the Pediatric Infectious Diseases Society | Oxford Academic
• Oral Valganciclovir Therapy in Infants Aged ≤2 Months with Congenital Cytomegalovirus Disease: A Multicenter, Single-Arm, Open-Label Clinical Trial in Japan - PMC

Clinical management

• Results of a multicenter registry for congenital cytomegalovirus infection in Flanders, Belgium: From prenatal diagnosis over neonatal management to therapy - ScienceDirect
• Cranial ultrasound and MRI: complementary or not in the diagnostic assessment of children with congenital CMV infection? - PubMed
• Differential congenital cytomegalovirus infection in dichorionic diamniotic twins—A case report and literature review - PMC
• Secondary cytomegalovirus infections: How much do we still not know? Comparison of children with symptomatic congenital cytomegalovirus born to mothers with primary and secondary infection - PMC
• Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection
• Changes in valganciclovir use among infants with congenital CMV diagnosis in the United States, 2009-2015 and 2016-2019 - ScienceDirect
• Incidence and impact of CMV infection in very low birth weight infants - PubMed